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Light-adjustable lens: development of in vitro nomograms.
Daniel M Schwartz1, Christian A Sandstedt, Shiao H Chang
1Beckman Vision Center, Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Transactions of the American Ophthalmological Society
|March 8, 2005
Summary
New digital patterns precisely correct myopia, hyperopia, and astigmatism in silicone light-adjustable lenses (LALs) in vitro. A novel pattern also effectively locks the lens without altering optical quality or power.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Materials Science
Background:
- Refractive errors like myopia, hyperopia, and astigmatism are common vision impairments.
- Current correction methods may have limitations, driving innovation in intraocular lens technology.
- Silicone light-adjustable lenses (LALs) offer potential for customizable vision correction.
Purpose of the Study:
- To develop digital spatial intensity patterns for precise in vitro correction of refractive errors using silicone LALs.
- To evaluate a new spatial intensity pattern for achieving effective 'lock-in' of the LAL in vitro.
Main Methods:
- A digital interferometer/irradiation system was used to apply UV light with specific spatial patterns to LALs.
- LALs were maintained at simulated ocular temperature (35°C) during irradiation.
- Post-irradiation, LAL power, optical quality, and macromer content (for lock-in) were analyzed.
Main Results:
- Digital spatial intensity patterns were successfully developed, enabling nomograms for correcting myopia, hyperopia, and astigmatism in ~0.25 D steps.
- Irradiation resulted in reproducible power changes without compromising the optical quality of the LALs.
- The 'lock-in' pattern effectively stabilized the LAL without significant changes in power or optical quality.
Conclusions:
- In vitro nomograms for silicone LALs allow for precise correction of myopia, hyperopia, and astigmatism.
- A spatial light intensity pattern was successfully devised to achieve LAL lock-in, preserving optical quality and power.