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Updated: Aug 19, 2026
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
Published on: August 28, 2013
Localized prostatic cancer in patients submitted to renal transplant
João C Campagnari1, Luiz A A Ribeiro, Marcelo Mangini
1Section of Urology and Nephrology, São Joaquim Hospital, Real e Benemérita Sociedade Portuguesa de Beneficência de São Paulo, SP, Brazil.
Objective:
An attempt is made to evaluate the incidence of prostate cancer in patients who have previously undergone a kidney transplant surgery and to determine the best therapeutic approach to this target group.
Material And Methods:
All kidney transplant male patients over 40 years of age were studied with respect to diseases unrelated to the transplants, which later affected them, mainly focusing on neoplastic disease and, more specifically, prostate cancer.
Results:
Of 397 kidney-transplanted patients, 146 (37%) were males, at least 40 years old. Among the 10 of them (6.8%) who developed neoplastic diseases, there were two cases (1.4%) of prostatic cancer. Both were treated with a radical retropubic prostatectomy with no technical difficulty, in spite of the presence of a graft in one of the iliac fossa.
Conclusions:
Prostate cancer incidence in kidney transplant patients is still low (1.8%), but it will certainly heighten as transplants are performed in increasingly older people and as better immunosuppressive drugs are introduced to lengthen the survival of grafts and patients. Because these cancers are expected to be more aggressive as a consequence of continuous immunosuppression, early diagnosis is of critical importance, and those patients should be made aware of the need for frequent screening for prostate cancer.
Insights
Prostate cancer incidence in kidney transplant recipients is low but rising. Early diagnosis and frequent screening are crucial due to potential increased aggressiveness from immunosuppression.
Area of Science:
- Nephrology
- Urology
- Oncology
Background:
- Kidney transplant recipients (KTRs) face unique health challenges, including an increased risk of certain cancers.
- Prostate cancer is a common malignancy in aging men, necessitating evaluation in KTRs.
Purpose of the Study:
- To assess the incidence of prostate cancer in male KTRs over 40.
- To identify optimal therapeutic strategies for prostate cancer in this specific patient population.
Main Methods:
- Retrospective analysis of male KTRs aged 40 and above.
- Focus on non-transplant-related neoplastic diseases, specifically prostate cancer.
Main Results:
- Two cases (1.4%) of prostate cancer were diagnosed among 146 eligible male KTRs (37% of total KTRs).
- Both patients underwent successful radical retropubic prostatectomy without surgical complications, even with an iliac fossa graft.
Conclusions:
- The incidence of prostate cancer in KTRs remains low (1.8%) but is projected to increase.
- Continuous immunosuppression may lead to more aggressive prostate cancer in KTRs, underscoring the importance of early detection and regular screening.
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