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[Significant decrease of recent thymic output function in patients with severe benzene intoxication].

Yang-Qiu Li1, Su-Fang Han, Li-Jian Yang

  • 1Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China. jn-yangqiuli@163.com

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|March 8, 2005
PubMed
Summary
This summary is machine-generated.

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Severe benzene poisoning significantly reduces T-cell receptor excision DNA circles (TREC) levels in patients. This indicates a decreased recent thymic output, potentially impairing T-cell immune function.

Area of Science:

  • Immunology
  • Toxicology
  • Molecular Biology

Context:

  • Benzene is a common industrial solvent with known hematotoxic effects.
  • Assessing recent thymic output is crucial for understanding T-cell homeostasis and immune competence.
  • T-cell receptor excision DNA circles (TREC) serve as reliable biomarkers for recent thymic emigrants.

Purpose:

  • To quantify T-cell receptor excision DNA circles (TREC) in patients with severe benzene poisoning.
  • To evaluate the impact of benzene toxicity on naive T-cell content and recent thymic output.
  • To establish a correlation between TREC levels and the severity of benzene-induced immune dysfunction.

Summary:

  • Quantitative real-time PCR was employed to measure TREC levels in peripheral blood mononuclear cells (PBMNC) from 16 healthy individuals and 8 patients with severe benzene poisoning.

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  • TREC levels were significantly lower in benzene-poisoned patients (1.03 +/- 0.44/1,000 PBMNCs) compared to normal individuals (6.69 +/- 4.79/1,000 PBMNCs) (P < 0.01).
  • Persistently low TREC levels were observed in benzene-intoxicated individuals, even when peripheral blood cell counts normalized, highlighting a specific impact on thymic output.

    • Impact:

    • The study demonstrates a marked decrease in recent thymic output function in patients suffering from severe benzene intoxication.
    • Reduced TREC levels suggest a compromised T-cell immune function due to benzene exposure.
    • Findings underscore the potential of TREC as a biomarker for monitoring benzene toxicity and its effects on the immune system.