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Published on: January 7, 2018
Advanced-glycation end products in insulin-resistant states
Georgia Soldatos1, Mark E Cooper, Karin A M Jandeleit-Dahm
1Baker Heart Research Institute, Commercial Road, Melbourne 3181, Victoria, Australia.
Abstract:
Insulin resistance is a central component of a number of clinical conditions, including the metabolic syndrome, diabetes, and hypertension. There is emerging evidence that the consequent hyperinsulinemia and visceral adiposity may be directly responsible for the excess cardiovascular morbidity and mortality seen in these conditions. Advanced-glycation end products, a chemically diverse group of compounds found in higher levels in insulin-resistant states, have also been shown to adversely affect endothelial function as well as activate numerous intracellular signaling pathways implicated in the atherosclerotic pathway. In this review, we summarize the factors thought to be important in both the initiation and exacerbation of the insulin-resistant state, and directly examine the potential role of advanced-glycation end products in this process.
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