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Cowden's syndrome.

Olympia Kovich¹, David Cohen

¹Ronald O. Perelman Department of Dermatology, New York University, USA.

Dermatology Online Journal

|March 8, 2005

Summary

This summary is machine-generated.

Cowden's syndrome is a rare genetic disorder causing benign growths and increasing cancer risk. Early screening and treatment of facial papules are crucial for managing this condition.

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Area of Science:

Dermatology
Oncology
Genetics

Background:

Cowden's syndrome is an autosomal dominant disorder.
It is characterized by hamartomas and an increased risk of neoplasias.

Observation:

A 59-year-old woman presented with facial papules (trichilemmomas).
She later developed breast, endometrial, and renal-cell carcinomas.
She also had a multinodular goiter requiring thyroidectomy.

Findings:

The patient's presentation and history are consistent with Cowden's syndrome.
This syndrome involves hamartomas and predisposes individuals to specific cancers.

Implications:

Medical management focuses on cancer screening (breast, thyroid, endometrial) and age-appropriate examinations.

Treatment options for facial papules include topical therapies, curettage, laser ablation, or surgical excision.