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Related Experiment Videos

Axillary granular parakeratosis.

Monika Srivastava1, David Cohen

  • 1Ronald O. Perelman Department of Dermatology, New York University, USA.

Dermatology Online Journal
|March 8, 2005
PubMed
Summary
This summary is machine-generated.

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A rare case of axillary granular parakeratosis occurred in a 71-year-old man. This condition, typically seen in women, presents as itchy, red, and thickened skin patches.

Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Axillary granular parakeratosis is an uncommon intertriginous eruption.
  • It typically affects middle-aged women, presenting as pruritic, erythematous, hyperkeratotic plaques.
  • Histological findings include parakeratosis with retained keratohyaline granules.

Observation:

  • A 71-year-old male presented with a pruritic eruption in the axilla.
  • Histopathologic examination revealed laminated orthokeratosis, parakeratosis, and hypergranulosis.

Findings:

  • The histopathologic findings were consistent with axillary granular parakeratosis.
  • This diagnosis is unusual given the patient's age and sex.

Implications:

  • The pathophysiology may involve a defective profilaggrin-filaggrin pathway.

Related Experiment Videos

  • Currently, there is a lack of evidence-based treatment options for this disorder.
  • This case highlights the importance of considering this diagnosis in a broader patient demographic.