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Updated: Aug 19, 2026

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro
Published on: August 28, 2019
Effects of CGS-12066A on medial vestibular nuclear neurons
Han-Seong Jeong1, Myung-Joo Jang, Jong-Seong Park
1Department of Physiology, Chonnam National University Medical School, Gwangju 501-190, South Korea.
Abstract:
This study aims to explore the effects of a selective 5-HT1B receptor agonist, CGS-12066A, on the neuronal excitability of the rat medial vestibular nuclear neurons. The spontaneous firing rate was decreased, and the membrane potential was hyperpolarized by CGS-12066A. The whole potassium currents were inhibited by CGS-12066A. After the calcium-dependent potassium, currents were blocked, however, CGS-12066A did not inhibit the potassium currents, suggesting that the 5-HT action site is calcium-dependent potassium currents.
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