Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The triplet genetic code had a doublet predecessor.

Apoorva Patel1

  • 1Centre for High Energy Physics and Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India. adpatel@cts.iisc.ernet.in

Journal of Theoretical Biology
|March 8, 2005
PubMed
Summary

The study suggests the 20 amino acids and triplet genetic code evolved from a simpler system. This involved duplicating 10 amino acids and a doublet genetic code, supported by evidence from synthetases, amino acids, and nucleotide bases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolated left upper extremity myositis and severe rhabdomyolysis in an adult with H1N1 Influenza, a case report with literature review.

IDCases·2016
Same author

Experimental implementation of local adiabatic evolution algorithms by an NMR quantum information processor.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2005
Same author

Carbon - the first frontier of information processing.

Journal of biosciences·2002
See all related articles

Area of Science:

  • Biochemistry
  • Genetics
  • Evolutionary Biology

Background:

  • The origin of the genetic code and the set of 20 amino acids is a fundamental question in molecular biology.
  • Previous hypotheses have explored various evolutionary pathways for the genetic code.

Purpose of the Study:

  • To investigate the evolutionary origins of the 20 naturally occurring amino acids and the triplet genetic code.
  • To propose a specific scenario for the code's evolution based on information theory and biochemical evidence.

Main Methods:

  • Information theoretic analysis of genetic languages.
  • Examination of properties of aminoacyl-tRNA synthetases.
  • Analysis of amino acid and nucleotide base characteristics.

Related Experiment Videos

Main Results:

  • Evidence suggests the 20 amino acids and triplet genetic code arose from the duplication of 10 class-II amino acids.
  • A primordial doublet genetic code with NNY codons and GNN anticodons is implicated.
  • The proposed scenario is supported by the properties of key biological molecules and enzymes.

Conclusions:

  • The study provides a plausible evolutionary pathway for the genetic code and amino acid set.
  • Duplication events played a crucial role in the development of genetic complexity.
  • Biochemical and informational analyses offer insights into the code's ancient origins.