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Related Experiment Videos

Urinary citrate in preterm and term babies.

Madeleine P White1, Narendra Aladangady, Hilary A Rolton

  • 1Department of Paediatrics and Neonatalogy, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK.

Early Human Development
|March 8, 2005
PubMed
Summary

Urinary citrate levels in healthy term babies show a wide normal range. Ex-preterm infants at term have similar urinary citrate, with no link to nephrocalcinosis or chronic lung disease.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Nephrology
  • Biochemistry

Background:

  • Urinary citrate plays a role in preventing kidney stones.
  • Establishing normal urinary citrate ranges is crucial for interpreting clinical findings in infants.
  • Preterm infants may have altered metabolic profiles.

Purpose of the Study:

  • To define the normal range of urinary citrate in healthy term newborns.
  • To compare urinary citrate levels in ex-preterm infants at term-corrected age with healthy term infants.
  • To investigate the association between urinary citrate and the presence of nephrocalcinosis (NC) and chronic lung disease (CLD) in ex-preterm infants.

Main Methods:

  • Urinary citrate and creatinine were measured in 38 healthy term infants (postnatal age 1-5 days).

Related Experiment Videos

  • Urinary citrate and creatinine were measured in 53 ex-preterm infants (<32 weeks gestation) at term-corrected age.
  • Renal ultrasounds were performed on ex-preterm infants at 1 month and term to assess for nephrocalcinosis.

    • Main Results:

    • The normal range for urinary citrate in term infants was 0.025-2.97 mmol/l (mean 1.03).
    • Ex-preterm infants had similar urinary citrate levels (mean 1.1 vs 1.03 mmol/l, p=0.7232) but a significantly higher citrate/creatinine ratio (mean 1.27 vs 0.27, p=0.0005) compared to term infants.
    • No significant differences in urinary citrate or related ratios were found between ex-preterm infants with or without NC or CLD.

    Conclusions:

    • A wide normal range for urinary citrate in term infants has been established.
    • Ex-preterm infants exhibit similar urinary citrate concentrations at term-corrected age.
    • Urinary citrate levels were not associated with nephrocalcinosis or chronic lung disease in this cohort of ex-preterm infants.