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Expression pattern of TG-interacting factor 2 during mouse development.

Lei Jin1, Yunhua Zhou, Chenzhong Kuang

  • 1Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Gene Expression Patterns : GEP
|March 8, 2005
PubMed
Summary
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TGIF2, a gene linked to developmental disorders, is widely expressed in the embryonic mouse nervous system and other organs. This suggests TGIF2 plays a crucial role in normal embryonic development.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • TGIF2 is a transcriptional corepressor, closely related to TGIF.
  • Mutations in TGIF are associated with holoprosencephaly, a forebrain and craniofacial developmental disorder.
  • Understanding TGIF2 expression is vital for insights into developmental processes.

Purpose of the Study:

  • To analyze the expression pattern of TGIF2 during mouse embryogenesis.
  • To identify the tissues and developmental stages where TGIF2 is expressed.

Main Methods:

  • Analysis of TGIF2 transcript expression patterns.
  • Utilized mouse embryogenesis models at E12.5 and E15.5.

Main Results:

  • TGIF2 transcripts were highly expressed in the embryonic mouse nervous system, including the neopallial cortex, midbrain, hindbrain, and spinal cord.

Related Experiment Videos

  • Expression was also detected in cranial and spinal ganglia (trigeminal, vestibulocochlear, dorsal root).
  • TGIF2 transcripts were found in various other developing organs like the heart, lung, liver, pancreas, kidney, small intestine, and nasal cavity.

    • Conclusions:

    • TGIF2 exhibits a broad yet tightly regulated expression profile during mouse development.
    • The widespread expression pattern suggests a significant role for TGIF2 in multiple developmental pathways.