Related Experiment Video
Updated: Aug 19, 2026

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
Published on: March 1, 2018
Development of a harmonized method for the profiling of amphetamines. I. Synthesis of standards and compilation of
Laura Aalberg1, Kjell Andersson, Christina Bertler
1National Bureau of Investigation, P.O. Box 285, FIN-01301 Vantaa, Finland.
Abstract:
Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra.
Related Concept Videos
Sample Preparation for Analysis: Overview
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
Development of Analytical Methods
Therapeutic Drug Monitoring: Drug Analysis Methods

