Related Experiment Video
Updated: Aug 13, 2026
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
Functional imaging of a large demyelinating lesion
1Wallace-Kettering Neurosciences Institute, Wright State University, Kettering Medical Center, 45429 OH., USA. vasanthapadma123@rediffmail.com
Purpose:
To determine the metabolic characterization of a large solitary demyelinating lesion.
Methods:
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
Results:
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
Conclusion:
The report summarizes the metabolic characteristics of a demyelinating plaque.
