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Related Experiment Videos

Heparanase improves mouse embryo implantation.

Ariel Revel1, Aharon Helman, Moriah Koler

  • 1Department of Gynecology, Hadassah-Hebrew Medical Center, Jerusalem, Israel. revel@md.huji.ac.il

Fertility and Sterility
|March 8, 2005
PubMed
Summary

Recombinant heparanase supplementation significantly improved mouse embryo implantation rates by nearly twofold. This suggests heparanase plays a crucial role in successful embryonic implantation and endometrial receptivity.

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Area of Science:

  • Reproductive biology
  • Developmental biology
  • Biochemistry

Background:

  • Heparanase, an enzyme degrading heparan sulfate, possesses enzymatic, angiogenic, and adhesive properties.
  • These properties suggest a potential role for heparanase in embryonic implantation and endometrial receptivity.
  • Improving endometrial receptivity is critical for addressing human fertility challenges.

Purpose of the Study:

  • To investigate the potential of recombinant heparanase supplementation to enhance mouse embryonic implantation.
  • To assess the impact of heparanase on endometrial receptivity and implantation success.

Main Methods:

  • Mouse morulae were incubated with or without recombinant heparanase.
  • Blastocysts were analyzed for heparanase expression and activity.

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  • Implantation rates were compared after transferring supplemented and control blastocysts to foster mice.

    • Main Results:

    • Heparanase is constitutively expressed in mouse morulae and blastocysts.
    • Supplementation with recombinant heparanase increased its expression and enzymatic activity in blastocysts.
    • Embryo implantation rates were significantly higher (36.9%) in the heparanase-supplemented group compared to controls (17.8% and 20%).

    Conclusions:

    • Heparanase is actively involved in the process of embryo implantation.
    • Recombinant heparanase supplementation can nearly double embryo implantation rates in vivo.
    • These findings highlight heparanase as a potential therapeutic target for improving fertility outcomes.