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Rat Mesentery Angiogenesis Assay
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An indirect quantitative method for the assessment of angiogenesis in human tissues

Christine Lawson1, Catherine Herrmann-Lavoie, André Lemay

  • 1Laboratoire d'Endocrinologie de la Reproduction, Centre de Recherche, Hôpital Saint-François d'Assise, Université Laval, Québec, Québec, Canada.

Fertility and Sterility
|March 8, 2005
PubMed

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...