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Related Experiment Videos

Pressure-dependent attenuation with microbubbles at low mechanical index.

Meng-Xing Tang¹, Robert J Eckersley, J Alison Noble

¹Wolfson Medical Vision Laboratory, Department of Engineering Science, Oxford University, Oxford, UK. mtang@robots.ox.ac.uk

Ultrasound in Medicine & Biology

|March 8, 2005

Summary

This summary is machine-generated.

Related Concept Videos

Excess Pressure Inside a Drop and a Bubble

Excess Pressure Inside a Drop and a Bubble

The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops.

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This study introduces a new model for ultrasound attenuation in microbubble contrast agents, showing a linear relationship between attenuation and acoustic pressure at low levels.

Area of Science:

Ultrasound physics
Biomedical acoustics
Medical imaging

Background:

Ultrasound (US) attenuation by microbubble contrast agents depends on acoustic pressure.
Previous models focused on single bubbles, not bulk volumes.

Purpose of the Study:

To develop a new pressure-dependent attenuation model for inhomogeneous volumes of attenuators.
To investigate the effect of attenuation on US propagation in bulk microbubble contrast agents.

Main Methods:

Proposed a novel pressure-dependent attenuation model for inhomogeneous attenuator volumes.
Validated the model using experimental measurements with the US contrast agent Sonovue.

Main Results:

The model considers the impact of attenuation on US propagation.

Related Experiment Videos

Experimental validation with Sonovue confirmed the model's predictions.

A linear relationship was observed between Sonovue attenuation (dB) and acoustic pressure at low levels.

Conclusions:

The new model accurately describes pressure-dependent ultrasound attenuation in microbubble contrast agents.
Findings are crucial for optimizing ultrasound imaging and therapy using contrast agents.