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Related Experiment Videos

Stem cell plasticity: time for a reappraisal?

Roberto M Lemoli1, Francesco Bertolini, Ranieri Cancedda

  • 1Istituto di Ematologia e Oncologia Medica L. e A. Seràgnoli, Università di Bologna, Bologna, Italia. rmlemoli@med.unibo.it

Haematologica
|March 8, 2005
PubMed
Summary

Adult stem cells (SC) show potential for tissue regeneration, but their plasticity remains controversial. This review examines SC function, differentiation capacity, and clinical applications in regenerative medicine.

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Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Recent publications suggest adult mammalian stem cells (SC) possess plasticity, enabling differentiation across tissue lineages.
  • This potential plasticity has been proposed as a novel therapeutic strategy for tissue regeneration.
  • However, the concept of somatic SC plasticity remains controversial, with elusive therapeutic perspectives.

Purpose of the Study:

  • To review the mechanisms governing stem cell (SC) function.
  • To examine the identification and functional characterization of adult SC from various tissues.
  • To discuss the potential for adult SC transdifferentiation and their clinical applications in regenerative medicine.

Main Methods:

  • Informal consensus development by a Working Group on Stem Cells.

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  • Multiple meetings were held to discuss assigned topics and reach agreement on differing opinions.
  • Review of articles from Science Citation Index and Medline, in addition to authors' original work.

    • Main Results:

    • Adult stem cells (SC) exhibit varying degrees of plasticity, with potential for transdifferentiation.
    • The functional characteristics and differentiation capacities of adult SC are tissue-specific.
    • Clinical applications for regenerative medicine are explored, highlighting both potential and challenges.

    Conclusions:

    • The plasticity of adult stem cells (SC) is a complex phenomenon requiring further investigation.
    • While promising for regenerative medicine, the therapeutic use of adult SC is still under development.
    • Continued research is essential to fully understand and harness the potential of SC for tissue repair.