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Related Experiment Videos

Systemic lactose intolerance: a new perspective on an old problem.

S B Matthews1, J P Waud, A G Roberts

  • 1Department of Medical Biochemistry and Immunology, Llandough Hospital, Cardiff and Vale NHS Trust, Penarth Vale of Glamorgan, UK.

Postgraduate Medical Journal
|March 8, 2005
PubMed
Summary
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Lactose intolerance symptoms are often missed due to hidden lactose in foods. A new diagnostic approach combines genetic testing, symptom tracking, and breath tests for better clinical management.

Area of Science:

  • Gastroenterology
  • Human Genetics

Background:

  • Food intolerance presents diverse gut and systemic symptoms.
  • Lactose intolerance diagnosis is complicated by hidden lactose in inadequately labeled foods.

Observation:

  • Two polymorphisms (C/T13910 and G/A22018) are linked to hypolactasia.
  • These polymorphisms correlate with breath hydrogen levels and symptom manifestation after lactose consumption.

Findings:

  • A novel diagnostic approach integrates genetic markers, a 48-hour symptom diary, and a 6-hour breath hydrogen test.
  • This method enhances the clinical management of lactose intolerance.

Implications:

  • Patients require education on "risk" foods containing hidden lactose, such as processed meats and baked goods.

Related Experiment Videos

  • Findings have significant implications for irritable bowel syndrome management and various medical specialties.