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Updated: Jul 31, 2026
Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Confirming positive results of nucleic acid amplification tests (NAATs) for Chlamydia trachomatis: all NAATs are not
J Schachter1, E W Hook, D H Martin
1Chlamydia Research Laboratory, Department of Laboratory Medicine, University of California-San Francisco, 1001 Potrero Ave., SFGH 3416, San Francisco, CA 94110, USA. jsch@itsa.ucsf.edu
Abstract:
The Centers for Disease Control and Prevention recommended confirming positive screening tests for Chlamydia trachomatis when positive predictive values are <90%. It is accepted that less sensitive tests (i.e., culture and immunoassays) should not be used to confirm the results of more sensitive nucleic acid amplification tests (NAATs). We show that the same principle applies when NAATs are used for confirmation.
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