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Updated: Aug 19, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility
Xiaosong Wang1, Massimiliano Ria, Peter M Kelmenson
1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. xw@jax.org
Abstract:
Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P
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