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Related Experiment Videos

Multimeric glycotherapeutics: new paradigm.

Nicolai V Bovin1, Alexander B Tuzikov, Alexander A Chinarev

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, Moscow V-437, 117997, Russia, bovin@carbohydrate.ru

Glycoconjugate Journal
|March 8, 2005
PubMed
Summary

Self-assembling glycopeptides offer a novel anti-adhesion therapy strategy. This approach overcomes drug size limitations for treating microbial infections and viral diseases.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Drug Discovery

Background:

  • Anti-adhesion therapy aims to prevent microorganism attachment using soluble receptor analogs.
  • Current limitations include the need for large molecules (multivalent) for efficacy versus small molecules for FDA approval.
  • The 'post-antibiotic era' lacks effective anti-adhesion therapeutics.

Purpose of the Study:

  • To propose a novel strategy for anti-adhesion therapy using self-assembling glycopeptides.
  • To overcome the contradiction between drug efficacy (multivalency) and regulatory approval (small molecule).
  • To develop therapeutics for the post-antibiotic era.

Main Methods:

  • Utilizing glycopeptides where carbohydrate moieties bind microbial lectins and peptide parts form tectomers.

Related Experiment Videos

  • Designing self-assembling tectomers, some responsive to specific microorganisms like influenza virus (sialopeptide).
  • Outlining a strategy: identify oligosaccharide-receptor, optimize peptide part, conduct trials.

    • Main Results:

    • Glycopeptides can self-assemble into tectomers, forming large, multivalent structures from small molecules.
    • Sialopeptide demonstrates microorganism-triggered tectomer formation.
    • The proposed strategy facilitates rapid lead identification and optimization.

    Conclusions:

    • Self-assembling glycopeptides present a viable solution to current anti-adhesion therapy challenges.
    • This approach promises complete and irreversible blocking of microorganisms.
    • Expected advantages include minimal side effects and reduced potential for microbial resistance.