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[Alterations of cardiac output during bicarbonate hemodialysis and its relationship with other hemodynamic

R Rivera1, G Arrigo, S Mandolfo

  • 1U.O. di Clinica Nefrologica, Ospedale di Monza. rfrmdphd@hotmail.com

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|March 8, 2005
PubMed

Insights

Hemodialysis (HD) causes a progressive reduction in cardiac output (CO) and an increase in total peripheral resistance (TPR). This hemodynamic shift is linked to fluid overload and ultrafiltration rate (UFR) during treatment.

Area of Science:

  • Cardiovascular Physiology
  • Renal Medicine
  • Hemodynamics

Context:

  • Hemodialysis (HD) is a life-sustaining treatment for end-stage renal disease.
  • Understanding hemodynamic changes during HD is crucial for patient management.
  • Previous studies have indicated potential cardiovascular stress during dialysis sessions.

Purpose:

  • To characterize the time course of cardiac output (CO) during hemodialysis.
  • To investigate the relationship between CO and other hemodynamic parameters.
  • To identify factors influencing CO reduction during HD.

Summary:

  • Cardiac output (CO) and cardiac index (CI) significantly decreased post-hemodialysis (p=0.001).
  • Total peripheral resistance (TPR) significantly increased post-hemodialysis (p=0.001).
  • CO reduction was primarily associated with ultrafiltration rate (UFR) and non-linearly with volume overload.

Impact:

  • Identifies a typical hemodynamic profile during moderate-ultrafiltration hemodialysis.
  • Suggests that progressive CO reduction and TPR increase are characteristic features.
  • Highlights the non-linear relationship between volume overload and CO changes.
Abstract

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