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Related Experiment Videos

Consensus based validation of membrane porins.

A V S K Mohan Katta1, Rajeshwari Marikkannu, Rajiv V Basaiawmoit

  • 1Bioinformatics Centre, School of Biotechnology, Madurai Kamaraj University, Madurai-625 021, India.

In Silico Biology
|March 9, 2005
PubMed
Summary
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A new validation mechanism and database (PRNDS) for outer membrane porins (beta-barrel proteins) have been developed. This resource aids target selection in proteomics and structural genomics by ranking and predicting porins.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Porins are outer membrane beta-barrel proteins with diverse biological roles, including phage receptors, immunogenicity, pathogenicity, and apoptosis.
  • Despite their importance, only a limited number of porins have been structurally and functionally characterized.
  • A validated database is needed for efficient target selection in proteomics and structural genomics.

Purpose of the Study:

  • To develop a validation mechanism for membrane porins.
  • To create a comprehensive database of porins, including experimentally validated and putative candidates.
  • To establish a system for ranking and predicting porins based on structural and sequence criteria.

Main Methods:

  • Development of a weighted scoring system based on six structure- and sequence-based criteria.

Related Experiment Videos

  • Creation of the Porin Ribonucleotide and Nucleotide Database Server (PRNDS).
  • Implementation of a validation and ranking system within the PRNDS server.

    • Main Results:

    • A novel validation mechanism for membrane porins has been successfully developed.
    • The PRNDS database has been established, containing experimentally proven and likely putative porins.
    • A weighted scoring system enables the validation and ranking of porins, with prediction capabilities included.

    Conclusions:

    • The developed validation mechanism and PRNDS database provide a valuable resource for researchers.
    • This tool facilitates target selection in proteomics and structural genomics by offering validated and ranked porin data.
    • PRNDS aids in the identification and characterization of novel porins through its predictive functions.