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Updated: Aug 19, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Consensus based validation of membrane porins
A V S K Mohan Katta1, Rajeshwari Marikkannu, Rajiv V Basaiawmoit
1Bioinformatics Centre, School of Biotechnology, Madurai Kamaraj University, Madurai-625 021, India.
Abstract:
Porins are outermembrane beta-barrel proteins. They have varied biological functionality ranging from phage receptors, immunogenicity, pathogenicity to apoptosis. However, only a small number has been structurally and functionally characterised. A validation mechanism and a database of porins would be useful for target selection in proteomics and structural genomics work. Here we report a validation mechanism developed for membrane porins. A database server for porins, PRNDS, has been created containing experimentally proven porins and likely putative porins. Each porin is validated and ranked using a weighted scoring system developed based on six, structure and sequence based criteria. The server also predicts possible porins.
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