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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin Cancer01:30

Skin Cancer

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Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

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Related Experiment Video

Updated: Jun 24, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Pityriasis versicolor alba.

W Thoma1, H-J Krämer, P Mayser

  • 1Center of Dermatology and Andrology, Gaffkystr. 14, D-35385 Giessen, Germany. wiebke.thoma@derma.md.uni-giessen.de

Journal of the European Academy of Dermatology and Venereology : JEADV
|March 9, 2005
PubMed
Summary
This summary is machine-generated.

Pityriasis versicolor alba presents as hypopigmented or depigmented skin lesions. The exact cause of depigmentation remains unclear, and current therapies show limited effectiveness for these specific lesions.

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Area of Science:

  • Dermatology
  • Mycology

Background:

  • Pityriasis versicolor alba is a variant of pityriasis versicolor, presenting with hypopigmented or depigmented maculous, scaly lesions.
  • Historically, long-persisting hypopigmentation post-infection was noted, later distinguished as a separate variant.
  • The condition is linked to yeasts of the genus Malassezia, though the specific species and pathogenesis of depigmentation are debated.

Observation:

  • Lesions are typically found in seborrhoeic areas.
  • The pathogenesis of depigmentation is not fully established.
  • Potential mechanisms include a screening effect of the scale layer or toxic effects of fungal metabolites on pigment synthesis.

Findings:

  • Tryptophan-derived metabolites from Malassezia furfur are suggested as significant factors in depigmentation.
  • Evidence-based therapeutic data for pityriasis versicolor alba is lacking.
  • Standard pityriasis versicolor treatment involves antimycotics and ultraviolet therapy, but ultraviolet therapy is often ineffective for depigmented lesions.

Implications:

  • Further research is needed to elucidate the pathogenesis of depigmentation in pityriasis versicolor alba.
  • Development of targeted therapies for depigmented lesions is warranted.
  • Understanding the role of Malassezia metabolites could lead to novel treatment strategies.