Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oculomotor performance in obsessive-compulsive disorder.

A Y Tien1, G D Pearlson, S R Machlin

  • 1Department of Mental Hygiene, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205.

The American Journal of Psychiatry
|May 1, 1992
PubMed
Summary

Individuals with obsessive-compulsive disorder (OCD) show impaired goal-guided saccadic eye movements, particularly in antisaccade tasks. This suggests a link between OCD diagnosis and oculomotor control deficits, with potential gender-specific differences.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Jang YJ, et al. Characterizing the relationship between personality dimensions and psychosis-specific clinical characteristics" [Schizophr Res. 276 (2025) 88-96 10.1016/j.schres.2025.01.002 (Epub ahead of print, PMID: 39864301, Jan 25)].

Schizophrenia research·2025
Same author

Identifying canonical and replicable multi-scale intrinsic connectivity networks in 100k+ resting-state fMRI datasets.

Human brain mapping·2023
Same author

Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and its Links to Genetic Risk.

bioRxiv : the preprint server for biology·2023
Same author

Emotional scene processing in biotypes of psychosis.

Psychiatry research·2023
Same author

Moving beyond the 'CAP' of the Iceberg: Intrinsic connectivity networks in fMRI are continuously engaging and overlapping.

NeuroImage·2022
Same author

Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

Translational psychiatry·2017

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Psychiatry

Background:

  • Neuroimaging reveals frontal cortex and basal ganglia abnormalities in obsessive-compulsive disorder (OCD).
  • Lesions in these brain areas are known to impact goal-guided saccadic eye movements.

Purpose of the Study:

  • To investigate the relationship between obsessive-compulsive disorder diagnosis and oculomotor performance.
  • To assess if OCD affects specific types of eye movements.

Main Methods:

  • Compared oculomotor performance in 11 OCD patients and 14 healthy controls.
  • Assessed visual-guided saccade tasks, goal-guided antisaccade tasks, and fixation performance.

Main Results:

  • OCD patients exhibited significantly higher error rates and inaccurate saccades on the antisaccade task.

Related Experiment Videos

  • No significant differences were found in reaction time, saccadic velocity, or accuracy on the visual-guided saccade task.
  • Abnormal findings were more prevalent in male OCD patients.

    • Conclusions:

    • Results support a link between impaired goal-guided saccadic eye movement and OCD diagnosis.
    • Findings suggest a potential gender-related subgroup within the OCD population.