Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV and human complement: inefficient virolysis and effective adherence.

Zoltán Bánki1, Heribert Stoiber, Manfred P Dierich

  • 1Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria and Ludwig-Boltzmann-Institute for AIDS research, Fritz-Pregl-Str. 3., 6020 Innsbruck, Austria.

Immunology Letters
|March 9, 2005
PubMed
Summary

Human immunodeficiency virus (HIV) envelope proteins activate the complement system directly. Complement regulatory proteins on HIV virions prevent viral destruction, enhancing infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virucidal Potential of 3,3',4,4',5,5'-Hexahydroxy-<i>trans</i>-Stilbene Against Respiratory Syncytial Virus.

Viruses·2025
Same author

Antibody cross-reactivity among alphaviruses in clinical practice.

Trends in microbiology·2025
Same author

Interleukin-12 encoded by the oncolytic virus VSV-GP enhances therapeutic antitumor efficacy by inducing CD8+ T-cell responses with a long-lived effector cell phenotype.

Journal for immunotherapy of cancer·2025
Same author

Changes in self-reported physical and mental health, behaviour and economic status among adults by known seropositivity and sociodemographic factors before and after the COVID-19 pandemic outbreak in Ischgl, Austria.

Frontiers in public health·2025
Same author

SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis.

Emerging microbes & infections·2024
Same author

Disproportionate preponderance of HPV genotypes associated with anogenital warts among HIV-positive MSM.

Frontiers in public health·2024

Area of Science:

  • Immunology
  • Virology
  • Complement System

Background:

  • HIV envelope proteins (gp120 and gp41) can activate the complement system independently of antibodies.
  • HIV acquires host complement regulatory proteins (CRPs) during budding.
  • These CRPs shield HIV from complement-mediated destruction (virolysis).

Purpose of the Study:

  • To review the intricate interactions between HIV and the complement system.
  • To elucidate the consequences of complement opsonization on HIV infection dynamics.

Main Methods:

  • Literature review of studies on HIV-complement interactions.
  • Analysis of mechanisms of complement activation by HIV proteins.
  • Examination of the role of CRPs in HIV immune evasion.

Related Experiment Videos

Main Results:

  • Direct complement activation by HIV gp120 and gp41 confirmed.
  • CRPs on HIV surface inhibit complement-mediated virolysis.
  • Inefficient virolysis leads to complement fragment deposition on virions.

Conclusions:

  • Complement system activation by HIV is antibody-independent.
  • CRPs facilitate HIV survival and evasion of immune clearance.
  • Complement opsonization promotes HIV interaction with susceptible cells, potentially enhancing infectivity.