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Vitamin E in uremia and dialysis patients
Francesco Galli1, Umberto Buoncristiani, Carmela Conte
1University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy. f.galli@unipg.it
Abstract:
Vitamin E therapy (based either on oral supplements or new dialysis methods such as vitamin E-coated hemodialysers) has been suggested to yield a better clinical outcome in hemodialysis (HD) patients than in other populations of patients. Among other factors, the presence of a modified vitamin E status might help to explain this apparently paradoxical response to vitamin E. In this study we investigated 104 regular HD patients. The results indicate that, besides having a low dietary intake, these subjects show some abnormalities in the levels and metabolism of vitamin E, such as a disproportion between plasma tocopherols and lipids, low levels of gamma-T, and CEHC accumulation. Although further studies are needed to confirm the clinical relevance of vitamin E therapy in HD, these findings might lead to recommending a higher vitamin E intake in these patients.
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