Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin E supplementation reverses the age-associated decrease in effective immune synapse formation in CD4+ T cells.

Tanvir Ahmed1, Melissa Marko, Dayong Wu

  • 1Nutritional Immunology Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. simin.meydani@tufts.edu

Annals of the New York Academy of Sciences
|March 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence in urban design: A systematic review.

Cities (London, England)·2026
Same author

The WEE1 inhibitor azenosertib broadly enhances efficacy of antibody-drug conjugates with topoisomerase I and microtubule inhibitor payloads.

iScience·2026
Same author

Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss.

bioRxiv : the preprint server for biology·2026
Same author

Feasibility of rearing broilers in open-sided houses for extended periods: impacts of feed withdrawal approaches on growth, carcass traits, and meat quality metrics.

Poultry science·2026
Same author

Dynamic Ensemble Learning with Transfer Learning for Fatigue Performance Prediction in Ni-Based Superalloys.

Materials (Basel, Switzerland)·2026
Same author

Cyclin E1 overexpression identifies a therapeutically relevant poor prognostic patient subgroup in high-grade serous ovarian cancer.

NPJ precision oncology·2026

Aging impairs T cell function by hindering immune synapse formation. Vitamin E (VE) supplementation in older mice improved the ability of CD4(+) T cells to form effective immune synapses, suggesting a potential therapeutic avenue.

Area of Science:

  • Immunology
  • Aging Research
  • Cell Signaling

Background:

  • Aging is linked to decreased T cell functionality, impacting immune responses.
  • Impaired T cell signaling in aging is attributed to ineffective immune synapse formation.
  • Previous research suggests a role for Vitamin E (VE) in cellular signaling.

Purpose of the Study:

  • To investigate the impact of aging on T cell immune synapse formation.
  • To determine if Vitamin E (VE) supplementation can enhance immune synapse formation in aged CD4(+) T cells.
  • To explore the mechanisms behind age- and VE-induced improvements in immune synapse formation.

Main Methods:

  • Confocal microscopy was used to compare immune synapse formation in T cells from young and old mice.
  • CD4(+) T cells were exposed to antigen-presenting cells to assess synapse efficacy.

Related Experiment Videos

  • In vitro and in vivo experiments evaluated the effects of Vitamin E (VE) supplementation on aged T cells.

    • Main Results:

    • Aged CD4(+) T cells exhibited a lower percentage of effective immune synapses compared to young T cells.
    • Vitamin E (VE) supplementation significantly increased the formation of functional immune synapses in aged CD4(+) T cells.
    • VE supplementation promoted the translocation of signaling proteins crucial for synapse formation.

    Conclusions:

    • Age-related decline in T cell function is associated with impaired immune synapse formation.
    • Vitamin E (VE) supplementation can restore and enhance immune synapse formation in aged CD4(+) T cells.
    • Further research is warranted to elucidate the precise mechanisms of VE's action on T cell signaling and synapse formation.