Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhaled alternatives to nitric oxide.

Stuart M Lowson1

  • 1Department of Anesthesiology, University of Virginia Health Services Foundation, Charlottesville, VA, USA.

Critical Care Medicine
|March 9, 2005
PubMed
Summary

Alternative inhaled vasodilators show promise for pulmonary hypertension management. Inhaled prostanoids are well-studied, with emerging interest in phosphodiesterase inhibitors and neuropeptides.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How did we reform our out of control massive transfusion protocol program?

Transfusion·2021
Same author

Percutaneous coronary interventions and antiplatelet therapy in the perioperative period.

Journal of cardiothoracic and vascular anesthesia·2007
Same author

Does enteral glutamine supplementation decrease infectious morbidity?

Surgical infections·2006
Same author

Does the addition of glutamine to enteral feeds affect patient mortality?

Critical care medicine·2005
Same author

Alternatives to nitric oxide.

British medical bulletin·2004
Same author

Inhaled prostacyclin for the treatment of pulmonary hypertension after cardiac surgery.

Critical care medicine·2002

Area of Science:

  • Pulmonary Medicine
  • Pharmacology

Background:

  • Inhaled nitric oxide is established for pulmonary hypertension.
  • Concerns regarding cost, toxicity, and outcome data for inhaled nitric oxide exist.
  • Interest is growing in alternative inhaled selective pulmonary vasodilators.

Purpose of the Study:

  • To review alternative inhaled selective pulmonary vasodilators studied to date.
  • To describe their molecular mechanisms, side effects, and physiological effects.

Main Methods:

  • Literature review of inhaled pulmonary vasodilators excluding nitric oxide.
  • Analysis of animal and clinical studies on alternative agents.

Main Results:

  • Several agents demonstrate comparable physiological effects to inhaled nitric oxide.
  • Inhaled prostanoids (prostacyclin, iloprost) are the most studied alternatives.
  • Phosphodiesterase inhibitors and neuropeptides are emerging therapies.

Conclusions:

  • Alternative inhaled vasodilators offer comparable physiological effects to inhaled nitric oxide.
  • Inhaled prostanoids are the leading alternatives currently.
  • Novel therapies like phosphodiesterase inhibitors and neuropeptides warrant further investigation.

Related Experiment Videos