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Advances in pediatric and adult asthma

Stanley J Szefler1, Andrea Apter

  • 1Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA. szeflers@njc.org

The Journal of Allergy and Clinical Immunology
|March 9, 2005
PubMed

Insights

Recent research on asthma origins and persistence in children and adults is reviewed. Advances in genetics and biomarkers are paving the way for individualized asthma management strategies.

Area of Science:

  • Pulmonology and Respiratory Medicine
  • Genetics and Genomics
  • Clinical Pharmacology

Background:

  • Previous reviews covered asthma genetics, upper airway management, costs, and early intervention.
  • Current review focuses on the origins and persistence of asthma in pediatric and adult populations.

Purpose of the Study:

  • To review recent publications (2004 onwards) on asthma pathogenesis.
  • To highlight advances in genetics, pharmacogenetics, respiratory infections, biomarkers, and pharmacotherapy.
  • To discuss the implications for future asthma management strategies.

Main Methods:

  • Literature review of journal publications from 2004 and recent key medical journal articles.
  • Synthesis of information on asthma genetics, pathogenesis, and emerging biomarkers.
  • Analysis of pharmacogenetic and pharmacotherapy advancements.

Main Results:

  • Significant progress in understanding asthma pathogenesis through genetic research.
  • Identification of key biomarkers for asthma assessment.
  • Emerging role of pharmacogenetics in tailoring asthma treatments.
  • Increased understanding of the impact of respiratory infections on asthma.

Conclusions:

  • New insights into asthma pathogenesis are emerging from genetic and biomarker research.
  • These advancements are expected to drive a shift towards individualized asthma management.
  • Future asthma care will likely move from group-based strategies to personalized approaches.

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