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Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression
Göran Landberg1, Kristina Nilsson, Karin Jirström
1Division of Pathology, Department of Laboratory Medicine, U-MAS, Lund University, Malmö, Sweden.
Abstract:
In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.
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