Related Experiment Video
Updated: Aug 19, 2026
Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
Cholinergic cortical circuits in Parkinson's disease and in progressive supranuclear palsy: a transcranial magnetic
Raffaele Nardone1, Igor Florio, Piergiorgio Lochner
1Department of Neurology, F. Tappeiner Hospital-Merano (BZ), Via Rossini, 5, 39012 Merano (BZ), Italy. raffaele.nardone@asbmeran-o.it
Abstract:
To investigate the involvement of the cortical cholinergic system in patients with Parkinson's disease (PD) and with progressive supranuclear palsy (PSP), we performed a comparative study of the short latency afferent inhibition (SAI) in ten patients with PD, in eight patients with PSP and in 15 healthy subjects. Six of the PD patients and four of the PSP patients had dementia. SAI was significantly increased in the PD patients, whereas it was not significantly different between PSP patients and the normal controls. Our findings demonstrate that the excitability of the motor cortex is differentially modulated by sensory afferents in PD and PSP and may indicate that the mechanisms of cholinergic dysfunction are different between the two diseases.
More Related Videos
14:47Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
Published on: April 21, 2023
08:29Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
Published on: November 7, 2025
