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Related Experiment Videos

Progressive language disorder due to lobar atrophy.

J S Snowden1, D Neary, D M Mann

  • 1Department of Neurology, Manchester Royal Infirmary, England.

Annals of Neurology
|February 1, 1992
PubMed
Summary

This study reveals progressive language disorder is not a single condition but a spectrum. Clinical and pathological findings show overlap with frontal lobe dementia, suggesting a link to non-Alzheimer lobar atrophy.

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Area of Science:

  • Neuroscience
  • Neurology
  • Linguistics

Background:

  • Progressive language disorder presents heterogeneously.
  • Anomia and mutism are common, but clinical features vary.
  • Associated symptoms can include agnosia or behavioral changes.

Purpose of the Study:

  • To characterize the clinical and pathological heterogeneity of progressive language disorder.
  • To investigate the relationship between progressive language disorder and other neurodegenerative conditions.
  • To explore the spectrum of non-Alzheimer lobar atrophy.

Main Methods:

  • Longitudinal study of 16 patients with progressive language disorder.
  • Neuropsychological assessments and neuroimaging (CT, SPECT).
  • Autopsy examination of 3 brains with distinctive clinical presentations.

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Main Results:

  • Patients showed diverse language profiles, from nonfluent to fluent aphasia with semantic loss.
  • Neuroimaging confirmed left-hemisphere or bilateral frontotemporal abnormalities.
  • Pathology revealed focal atrophy, gliosis, and spongiform changes without senile plaques or neurofibrillary tangles.

Conclusions:

  • Progressive language disorder is clinically heterogeneous.
  • Pathological findings overlap with frontal lobe dementia.
  • Progressive language disorder may represent a spectrum of non-Alzheimer lobar atrophy.