Related Experiment Videos
Paranasal sinus involvement in acute lymphoblastic leukemia
Bo-Hung Chang1, Ying-Lin Chen, Ta-Jen Lee
1Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei.
Chang Gung Medical Journal
|March 10, 2005
Summary
Acute lymphoblastic leukemia (ALL) can rarely affect the sinonasal area, causing orbital complications. Early evaluation and endoscopic sinus surgery are crucial for diagnosis and treatment in ALL patients with sinusitis.
Area of Science:
- Oncology
- Otorhinolaryngology
- Ophthalmology
Background:
- Acute lymphoblastic leukemia (ALL) is a bone marrow cancer that infrequently involves the sinonasal region.
- Sinonasal infiltration in ALL can lead to severe rhinosinusitis and orbital complications requiring prompt intervention.
Observation:
- A 26-year-old male with relapsed ALL presented with rapidly worsening periorbital pain and exophthalmos.
- Sinus CT revealed opacification of the right maxillary and ethmoid sinuses with orbital bone destruction.
Findings:
- Endoscopic sinus surgery (ESS) facilitated orbital decompression and obtained tissue for diagnosis.
- Histopathology confirmed lymphoblast infiltration and respiratory mucosa inflammation, with bone marrow cytology indicating a second ALL relapse.
Implications:
- Patients with ALL and sinusitis require evaluation for obstructive causes.
- ESS is effective for diagnosing sinonasal ALL infiltration and managing associated orbital complications.