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Methotrexate in resistant ENL.

Bikash R Kar1, Ravindra Babu

  • 1Dept. of Dermatology, Schieffelin Leprosy Research & Training Center, Karigiri, Vellore, South India. karbikash@hotmail.com

International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
|March 10, 2005
PubMed
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This case report details managing severe, steroid-resistant Type 2 reaction using methotrexate and prednisolone. This drug combination offers a preferred treatment option when other therapies like thalidomide are unavailable.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Type 2 reaction, a severe dermatological condition, often presents with steroid resistance.
  • Management of severe Type 2 reactions typically involves agents like thalidomide.

Observation:

  • A case of severe, steroid-resistant Type 2 reaction was observed.
  • The patient's condition necessitated alternative therapeutic strategies.

Findings:

  • The combination of methotrexate and prednisolone was employed for management.
  • This dual-drug approach demonstrated efficacy in treating the severe, steroid-resistant Type 2 reaction.

Implications:

  • Methotrexate and prednisolone represent a viable and preferred treatment combination for severe Type 2 reactions.

Related Experiment Videos

  • This combination is particularly valuable when first-line agents such as thalidomide are contraindicated or unavailable.