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Published on: December 19, 2020
Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides
Colleen Olive1, K Hsien, A Horváth
1Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Division of Infectious Diseases and Immunology, Herston, Brisbane, Qld 4029, Australia. colleenO@qimr.edu.au
Abstract:
We have investigated the lipid polylysine core peptide (LCP) system as a self-adjuvanting group A streptococcal (GAS) vaccine delivery approach. LCP constructs were synthesised incorporating peptides from the M protein conserved carboxy terminal C-repeat region, the amino terminal type-specific region and from both of these regions. Immunisation with the constructs without adjuvant led to the induction of peptide-specific serum IgG antibody responses, heterologous opsonic antibodies, and complete protection from GAS infection. These data indicate that protective immunity to GAS infection can be evoked using the self-adjuvanting LCP system, and point to the potential application of this system in human mucosal GAS vaccine development.
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