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Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells

Jin Park1, Qian Li, Young-Tae Chang

  • 1Department of Pharmacy, College of Pharmacy, Chonnam National University, Gwangju 500-757, Republic of Korea.

Bioorganic & Medicinal Chemistry
|March 10, 2005
PubMed

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...