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Influence of apolipoprotein E genotype on fat-soluble plasma antioxidants in Spanish children

Henar Ortega1, Patricia Castilla, Diego Gómez-Coronado

  • 1Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain.

The American Journal of Clinical Nutrition
|March 10, 2005
PubMed

Insights

Apolipoprotein E genotype influences children's fat-soluble antioxidant levels, primarily through its effect on lipid concentrations. However, specific genotypes like E2/2 show elevated tocopherol levels, indicating a complex relationship.

Area of Science:

  • Nutritional Science
  • Genetics
  • Biochemistry

Background:

  • Apolipoprotein E (apoE) significantly impacts plasma lipid levels.
  • Lipid concentrations, in turn, affect fat-soluble vitamin levels.
  • Understanding apoE's role in nutrient status is crucial for public health.

Purpose of the Study:

  • To investigate the influence of Apolipoprotein E (APOE) genotype on fat-soluble antioxidant concentrations in children.
  • To explore the relationship between APOE genotype, lipid profiles, and antioxidant status.

Main Methods:

  • Genotyping of the APOE gene in 926 healthy children (aged 6-8 years) from Spain.
  • Measurement of plasma lipid, apolipoprotein, and lipid-soluble antioxidant concentrations.
  • Statistical analysis including multivariate regression to identify influencing factors.

Main Results:

  • APOE genotype significantly affected plasma lipid concentrations.
  • Plasma levels of alpha-tocopherol, gamma-tocopherol, lycopene, and alpha-carotene showed variations based on APOE genotype.
  • Most genotype-specific differences in antioxidants were normalized after adjusting for lipoprotein covariates, except for elevated tocopherol in E2/2 individuals.
  • Interactions between APOE genotype, triacylglycerol, and apo B were identified as determinants of alpha-tocopherol levels.

Conclusions:

  • The link between APOE genotype and lipophilic antioxidant levels is largely mediated by APOE's effect on lipoprotein concentrations.
  • Triacylglycerol specifically influences alpha-tocopherol variability in E2 allele carriers.
  • These findings suggest that APOE genotype modulates the alpha-tocopherol content within different lipoprotein classes.
Abstract

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