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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Teaching resources. Protein domains that interact with receptor tyrosine kinases: structural aspects
1Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA. ming-ming.zhou@mssm.edu <ming-ming.zhou@mssm.edu>
Abstract:
This Teaching Resource provides lecture notes and slides for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.
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