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Infectious arthritis in patients with rheumatoid arthritis
L Mateo Soria1, J Miquel Nolla Solé, A Rozadilla Sacanell
1Rheumatology Service, Hospital de Bellvitge Princeps d'Espanya, University of Barcelona.
Annals of the Rheumatic Diseases
|March 1, 1992
Summary
Infectious arthritis in rheumatoid arthritis patients is often caused by Staphylococcus aureus. However, Mycobacterium tuberculosis infections can be delayed, leading to poorer outcomes.
Area of Science:
- Rheumatology
- Infectious Diseases
- Microbiology
Background:
- Rheumatoid arthritis (RA) patients have an increased risk of infections.
- Septic arthritis is a serious complication that can worsen RA prognosis.
Purpose of the Study:
- To report cases of infectious arthritis in RA patients.
- To analyze causative organisms, diagnostic delays, and outcomes.
- To highlight the importance of considering diverse pathogens, including Mycobacterium tuberculosis.
Main Methods:
- Retrospective case series.
- Analysis of clinical data, microbiological findings, and patient outcomes.
Main Results:
- Eleven cases of infectious arthritis in RA patients were identified.
- Staphylococcus aureus was the most common pathogen (8 cases).
- Mycobacterium tuberculosis caused two cases with significantly delayed diagnosis (mean 57 days vs. 16 days for pyogenic arthritis).
- Four patients died, associated with longer diagnostic times and polyarticular involvement.
Conclusions:
- While Staphylococcus aureus is a frequent cause, Mycobacterium tuberculosis should be considered in RA patients with joint infections.
- Delayed diagnosis, particularly for tuberculous arthritis, is linked to mortality.
- Prompt diagnosis and appropriate treatment are crucial for improving outcomes in RA patients with infectious arthritis.
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