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Updated: Aug 19, 2026

The Soft Agar Colony Formation Assay
Published on: October 27, 2014
Wingless signaling pathway family relation to colon cancer. Have we come full circle?
Khawla S Al-Kuraya1, Kishor G Bhatia
1Biological Repository Centre, King Faisal Specialist Hospital and Research Centre, MBC 98-16, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. kkuraya@kfshrc.edu.sa
Abstract:
Colorectal cancer CRC is one of the most common malignancies worldwide. Advances in molecular techniques have provided deep insight into the molecular pathogenesis, biologic and genetic changes occurring in colon cancer patients. Current theories of malignant transformation postulate that development of colon cancer is related to 2 main pathways; the loss of heterozygosity pathway, which is usually due to a defect in the adenomatous polyposis coli APC gene and microsatellite instability, which is usually due to a defect in mismatch repair MMR genes. This review summarizes the role of the wingless signaling pathway genes including APC and MMR genes in the development of CRC.
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