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Pyridalyl, a novel insecticide: potency and insecticidal selectivity.

S Isayama1, S Saito, K Kuroda

  • 1Crop Protection Division, Tokyo Head Office, Sumitomo Chemical Co. Ltd., Tokyo, Japan. isayama@sc.sumitomo-chem.co.jp

Archives of Insect Biochemistry and Physiology
|March 10, 2005
PubMed
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Pyridalyl is a novel insecticide highly effective against pests like Spodoptera litura and Frankliniella occidentalis. It shows low toxicity to beneficial insects such as Bombus terrestris and non-target cell lines, suggesting its potential for Integrated Pest Management (IPM).

Area of Science:

  • Agricultural Entomology
  • Insect Toxicology
  • Chemical Ecology

Background:

  • Pyridalyl represents a new class of insecticides with an unclassified mode of action.
  • Understanding its selectivity is crucial for sustainable pest control strategies.

Purpose of the Study:

  • To evaluate the insecticidal efficacy of pyridalyl against key agricultural pests.
  • To assess the toxicity of pyridalyl to non-target organisms, including pollinators and predators.
  • To determine the cytotoxicity of pyridalyl on insect and mammalian cell lines.

Main Methods:

  • Laboratory bioassays using leaf-dipping and direct spray methods for insecticidal activity.
  • Toxicity assessments on insect predator (Orius stringicollis) and pollinator (Bombus terrestris) via body-dipping and direct spray.

Related Experiment Videos

  • Cytotoxicity evaluation using the trypan-blue exclusion method on Sf9 (insect) and CHO-K1 (mammalian) cell lines.

    • Main Results:

    • Pyridalyl demonstrated high efficacy against all developmental stages of Spodoptera litura.
    • Toxicity to Frankliniella occidentalis was comparable to or greater than acrinathrin.
    • No acute toxicity was observed in Orius stringicollis or Bombus terrestris, with no impact on bee nests.
    • Pyridalyl exhibited high toxicity to insect cells but negligible toxicity to mammalian cells.

    Conclusions:

    • Pyridalyl displays significant insecticidal activity and high selectivity, sparing beneficial insects and exhibiting minimal mammalian cytotoxicity.
    • Its selective profile suggests potential for use in Integrated Pest Management (IPM) programs, particularly in greenhouse cultivation.