Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Anaesthesiologic problems about hyperthermic intraoperative intraperitoneal chemotherapy].

L Izzo1, F Pierannunzi, A Vari

  • 1Università degli Studi La Sapienza--Roma, Dipartimento di Chirurgia P. Valdoni.

Il Giornale Di Chirurgia
|March 11, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of sodium thiosulfate in prevention of aki in oncologic patient that underwent hipec (Hyperthermic Intraperitoneal Chemotherapy) with Cisplatin: a Case Report.

La Clinica terapeutica·2026
Same author

Cell-type-dependent expression of a somatic tri-allelic pattern at D18S51 and Penta D: The statistical interpretation of forensic evidence in sexual assault investigations.

Forensic science international. Genetics·2026
Same author

Editorial Expression of Concern: Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1.

Cell death and differentiation·2025
Same author

Advancing multiplex diagnostics: A novel framework for simultaneous detection of diverse pathogens using respiratory RNA viruses as a model system.

Journal of immunological methods·2025
Same author

Prognostic value of specific KRAS mutations in patients with colorectal peritoneal metastases.

ESMO open·2024
Same author

Once upon a time: the glucagon stimulation test in diagnosing adult GH deficiency.

Journal of endocrinological investigation·2024

Hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) is effective for ovarian cancer peritoneal metastasis. Monitoring hemodynamic and biochemical parameters during HIIC can help predict and manage complications, improving patient outcomes.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Chemotherapy

Context:

  • Peritoneal carcinomatosis, particularly from ovarian cancer, presents significant treatment challenges.
  • Hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) is a recognized approach for managing peritoneal metastasis.
  • Technical refinements in HIIC are needed to optimize safety and efficacy.

Purpose:

  • To evaluate the safety and feasibility of a specific HIIC protocol in patients with ovarian cancer and peritoneal metastasis.
  • To monitor hemodynamic and biochemical parameters during HIIC.
  • To correlate observed parameter variations with potential postoperative complications.

Summary:

  • Five female patients (age 27-45, ASA 2) with ovarian neoplasia and peritoneal metastasis underwent peritonectomy followed by HIIC.

Related Experiment Videos

  • A heated solution (43°C) of dextrose 1.5% with mitomycin C (25 mg) and cisplatin (75 mg/m²) was administered intraoperatively.
  • Hemodynamic (blood pressure, central venous pressure, stroke volume) and biochemical (electrolytes, CO2) parameters were closely monitored.

    • Impact:

    • This study highlights the importance of vigilant monitoring during HIIC to anticipate and mitigate risks such as fistula, anastomotic leakage, pancreatitis, and bleeding.
    • Findings contribute to refining HIIC protocols for peritoneal carcinomatosis, potentially improving patient safety and treatment success rates.
    • The data provides a basis for further research into predictive markers for HIIC-related complications in gynecological oncology.