Related Experiment Video

Updated: Aug 19, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Abnormal myocardial perfusion and contractile recruitment during exercise in type 1 diabetic patients

Roldano Scognamiglio1, Christian Negut, Saula Vigili de Kreuizenberg

  • 1Metabolic Cardiology Unit, Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy. r.scognamiglio@unipd.it

Clinical Cardiology
|March 11, 2005
PubMed

Insights

Type 1 diabetes mellitus (T1DM) patients show impaired myocardial perfusion during exercise, linked to reduced left ventricular ejection fraction. This defective increase in blood flow impacts the heart's ability to adapt to stress.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Type 1 diabetes mellitus (T1DM) is associated with progressive cardiac dysfunction, but the underlying mechanisms, particularly concerning myocardial perfusion, remain unclear.
  • No prior data exists on the relationship between myocardial perfusion and left ventricular (LV) function in T1DM patients without complications.

Purpose of the Study:

  • To investigate whether myocardial perfusion abnormalities are present at rest and during exercise in T1DM patients.
  • To determine if these perfusion abnormalities correlate with impaired LV contractile function in T1DM.

Main Methods:

  • Assessed 22 T1DM patients and 10 controls using two-dimensional and myocardial contrast echocardiography.
  • Evaluated LV function and myocardial perfusion at rest and during handgrip exercise.
  • Stratified T1DM patients into two groups based on LV ejection fraction response during exercise.

Main Results:

  • T1DM patients exhibited normal basal myocardial blood volume (MBV) and velocity (beta).
  • During exercise, T1DM patients, particularly those with declining LV ejection fraction, showed a blunted increase in MBV and beta compared to controls.
  • A strong correlation was found between the ratio of exercise to resting myocardial blood flow and LV ejection fraction during peak exercise in T1DM.

Conclusions:

  • A significant proportion of T1DM patients display impaired myocardial adaptive capacity to acute stress.
  • This impairment is associated with a defective increase in myocardial perfusion during exercise.
  • Abnormalities in myocardial perfusion may contribute to the development of diabetic cardiomyopathy in T1DM.
Abstract

More Related Videos

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Related Concept Videos

Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...