Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Future of allergen-specific immunotherapy.

Cezmi A Akdis

    Expert Opinion on Emerging Drugs
    |March 11, 2005
    PubMed
    Summary

    Allergen-specific immunotherapy (SIT) offers desensitization for allergies but can cause severe side effects. New strategies using recombinant DNA and peptide chemistry aim to create safer, more effective SIT vaccines.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Circulating CD38<sup>+</sup> regulatory T cells are decreased in bone fracture non-union with chronic subclinical infection.

    Scientific reports·2026
    Same author

    Respiratory Viral Infections and the Tonsillar Transcriptome: An Exploratory Study.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
    Same author

    Effects of Common Food Additives Kappa-, Iota- and Lambda-Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
    Same author

    The Rising Tide of Allergic Rhinitis in China: Driving Innovation Forward.

    Allergy·2026
    Same author

    Risk and Protective Factors for Infection, Severe Disease, and Mortality in Epidemic Respiratory Viruses.

    Allergy·2026
    Same author

    Polyethylene Terephthalate Micro and Nanoplastics Induce Oxidative and Endoplasmic Reticulum Stress, Compromising Intestinal Epithelial Integrity and Viability.

    Allergy·2026

    Area of Science:

    • Immunology
    • Allergy Research
    • Vaccine Development

    Background:

    • Allergen-specific immunotherapy (SIT) has been a long-standing treatment for allergic diseases, demonstrating effectiveness with careful patient selection.
    • Traditional allergen extracts, while effective, pose risks due to nonallergenic or toxic proteins, potentially causing severe adverse events like anaphylaxis.

    Discussion:

    • Recombinant DNA technology and peptide chemistry offer advanced methods to engineer SIT vaccines with significantly reduced allergenic potential.
    • Understanding the immunological basis of SIT, especially the function of regulatory T cells in peripheral tolerance, is crucial for developing improved therapies.

    Key Insights:

    • Novel SIT vaccines can be produced with lower allergenic activity using modern biotechnological approaches.
    • Regulatory T cells play a pivotal role in establishing allergen-specific peripheral tolerance, a key mechanism targeted by effective immunotherapy.

    Outlook:

    • Future SIT strategies will likely leverage these advancements to create safer and more targeted treatments for allergic conditions.
    • Continued research into immunological mechanisms promises to unlock new therapeutic avenues for managing allergies effectively.

    Related Experiment Videos