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Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin
1Department of Urology and Biochemistry, School of Medicine, Kinki University, Osaka, Japan.
Biochemical and Biophysical Research Communications
|April 30, 1992
Abstract:
We have sequenced a cDNA of urinary stone protein. cDNA sequences show complete homology between urinary stone protein and human osteopontin (bone sialoprotein) (nucleotides 265-886 and 1183-1424). Osteopontin is a recently discovered bone matrix protein which has been implicated in mediating mineral formation within bone extracellular matrix. This result shows that osteopontin is presumably involved in stone formation as stone matrix.