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Left ventricular function in children with sleep-disordered breathing

Raouf S Amin1, Thomas R Kimball, Maninder Kalra

  • 1Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. aminr@chmcc.org

The American Journal of Cardiology
|March 11, 2005
PubMed

Insights

Severe obstructive sleep apnea in children can cause heart failure. This study found that worsening obstructive sleep apnea leads to a dose-dependent decrease in diastolic function, indicating early cardiac changes.

Area of Science:

  • Pediatric Cardiology
  • Sleep Medicine
  • Cardiovascular Physiology

Background:

  • Obstructive sleep apnea (OSA) is a common pediatric condition.
  • Severe OSA is linked to adverse cardiovascular outcomes, including congestive heart failure.
  • Early detection of cardiac dysfunction in pediatric OSA is crucial.

Purpose of the Study:

  • To investigate early alterations in left ventricular function in children with obstructive sleep apnea.
  • To assess the relationship between the severity of obstructive sleep apnea and left ventricular diastolic function.

Main Methods:

  • Echocardiographic assessment of left ventricular diastolic function.
  • Quantification of obstructive sleep apnea severity (e.g., using apnea-hypopnea index).
  • Correlation analysis between OSA severity and diastolic parameters.

Main Results:

  • A significant decrease in diastolic function was observed in children with obstructive sleep apnea.
  • Diastolic dysfunction showed a dose-dependent relationship with the severity of obstructive sleep apnea.
  • These findings suggest early cardiac changes even before overt heart failure.

Conclusions:

  • Obstructive sleep apnea in children is associated with impaired left ventricular diastolic function.
  • The degree of diastolic dysfunction correlates with the severity of obstructive sleep apnea.
  • Early identification and management of pediatric OSA may prevent long-term cardiovascular complications.

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