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Left ventricular function in children with sleep-disordered breathing.

Raouf S Amin1, Thomas R Kimball, Maninder Kalra

  • 1Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. aminr@chmcc.org

The American Journal of Cardiology
|March 11, 2005
PubMed
Summary

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Relationship of Circadian Blood Pressure Dysregulation With Left Ventricular Structure and Function in Children With Obstructive Sleep Apnea.

Journal of sleep research·2025

Severe obstructive sleep apnea in children can cause heart failure. This study found that worsening obstructive sleep apnea leads to a dose-dependent decrease in diastolic function, indicating early cardiac changes.

Area of Science:

  • Pediatric Cardiology
  • Sleep Medicine
  • Cardiovascular Physiology

Background:

  • Obstructive sleep apnea (OSA) is a common pediatric condition.
  • Severe OSA is linked to adverse cardiovascular outcomes, including congestive heart failure.
  • Early detection of cardiac dysfunction in pediatric OSA is crucial.

Purpose of the Study:

  • To investigate early alterations in left ventricular function in children with obstructive sleep apnea.
  • To assess the relationship between the severity of obstructive sleep apnea and left ventricular diastolic function.

Main Methods:

  • Echocardiographic assessment of left ventricular diastolic function.
  • Quantification of obstructive sleep apnea severity (e.g., using apnea-hypopnea index).
  • Correlation analysis between OSA severity and diastolic parameters.

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Main Results:

  • A significant decrease in diastolic function was observed in children with obstructive sleep apnea.
  • Diastolic dysfunction showed a dose-dependent relationship with the severity of obstructive sleep apnea.
  • These findings suggest early cardiac changes even before overt heart failure.

Conclusions:

  • Obstructive sleep apnea in children is associated with impaired left ventricular diastolic function.
  • The degree of diastolic dysfunction correlates with the severity of obstructive sleep apnea.
  • Early identification and management of pediatric OSA may prevent long-term cardiovascular complications.