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Some vegetables (commonly consumed by humans) efficiently modulate bone metabolism.

R C Mühlbauer1, F Li, A Lozano

  • 1Bone Biology Group, Department Clinical Research, University of Bern, Switzerland. roman.muhlbauer@dkf5.unibe.ch

Journal of Musculoskeletal & Neuronal Interactions
|March 11, 2005
PubMed
Summary

Certain vegetables significantly impact bone metabolism. Daily onion intake increased bone mineral content and density, while reducing bone resorption in rats, suggesting a potential dietary approach for osteoporosis prevention.

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Area of Science:

  • Nutritional Science
  • Bone Biology
  • Pharmacology

Background:

  • Dietary components can influence bone metabolism.
  • Osteoporosis is a significant public health concern.
  • Investigating natural modulators of bone health is crucial.

Purpose of the Study:

  • To investigate the effects of dietary vegetables on bone metabolism in rats.
  • To identify specific vegetables that modulate bone resorption and bone mineral density.
  • To explore a potential nutritional strategy for osteoporosis.

Main Methods:

  • Rats were fed a semi-purified diet with added vegetable material.
  • Bone parameters were assessed using peripheral quantitative computed tomography (pQCT).
  • Bone resorption (BR) was measured by urinary [3H]-tetracycline excretion.

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Main Results:

  • Daily onion administration (1 g) increased bone mineral content (+17.4%) and trabecular bone mineral density (+13.6%).
  • Onion significantly blunted bone resorption by 23% in male rats and dose-dependently in ovariectomized rats.
  • Thirteen additional vegetables showed significant effects on bone resorption; soy, skimmed milk, meat, and egg were ineffective.

Conclusions:

  • Common vegetables possess potent modulators of bone metabolism.
  • Dietary vegetables, particularly onions, show promise in a nutritional approach to osteoporosis.
  • Further research could lead to low-cost, safe, and effective dietary interventions for bone health.