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Updated: Aug 18, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Chemotherapy-induced peripheral neuropathy
Terri Armstrong1, Lois Almadrones, Mark R Gilbert
1Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. tsarmstr@mdanderson.org
Purpose/Objectives:
To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy.
Data Sources:
Published abstracts, primary research literature, and textbook chapters.
Data Synthesis:
Recent improvements in the management of other treatment-related toxicities have led to peripheral neuropathy becoming a dose-limiting toxicity of commonly used chemotherapeutic groups such as platinols, vinca alkaloids, and taxanes.
Conclusions:
The nervous system has not been the focus of education or training for oncology nurses. Therefore, nurses' ability to educate patients regarding this aspect of their condition has been limited.
Implications For Nursing:
With its significant impact on quality of life, peripheral neuropathy treatment and prevention are important components in the care of patients with cancer.
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