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Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

Pregnancies in renal transplant recipients--with a focus on babies

A A Al-Khader1, N Basri, Al-Ghamdi

  • 1Hypertension and Renal Transplantation, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia. aaalkhader@hotmail.com

Annals of Transplantation
|March 12, 2005
PubMed

Insights

Pregnancies after kidney transplants resulted in many preterm births and lower birth weights. However, children showed no major defects or kidney issues, though breastfeeding was not advised due to medication.

Area of Science:

  • Nephrology
  • Obstetrics
  • Pediatrics

Background:

  • Renal transplant recipients face unique challenges during pregnancy.
  • Understanding pregnancy outcomes in this population is crucial for maternal and infant health.

Purpose of the Study:

  • To evaluate the outcomes of pregnancies in women who have received kidney transplants.
  • To assess the health and development of infants born to renal transplant recipients.

Main Methods:

  • Retrospective study of 113 pregnancies in 72 renal transplant recipients.
  • Analysis of delivery methods, gestational age, birth weight, Apgar scores, and congenital defects.
  • Long-term follow-up of children for renal function and development.

Main Results:

  • High incidence of preterm delivery (64%) and lower birth weights observed.
  • Vaginal delivery in 28%, Cesarean section in 72%.
  • Low incidence of congenital defects; no significant renal or developmental issues found in 41 children up to 52 months, despite maternal cyclosporine exposure.

Conclusions:

  • While pregnancies in renal transplant recipients often result in preterm birth and low birth weight, infants generally have good outcomes.
  • Long-term follow-up indicates no significant renal abnormalities or developmental delays in children exposed to cyclosporine in utero.
  • Breastfeeding is not recommended due to the presence of cyclosporine in maternal milk.

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