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Updated: Aug 19, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Microwave-promoted Suzuki reactions of aryl chlorides in aqueous media
Guobin Miao1, Ping Ye, Libing Yu
1ArQule Inc., 19 Presidential Way, Woburn, Massachusetts 01801, USA. lyu@arqule.com
Abstract:
[reaction: see text] The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-mu-chlorodichlorobis(di-tert-butylphosphinito-kappaP)dipalladate (2-)). This catalyst system under microwave conditions (150 degrees C, 15 min) provided coupled products with yields ranging from 64% to 99%. This method tolerated a variety of substituents and sterically hindered substrates.
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